This research combines large-scale multispectral remote sensing (RS) techniques using high-resolution satellite imagery, archaeological survey, and archival research, to investigate the colonial landscape of the central highlands of Peru, and how indigenous communities negotiated the creation of new post-Toledan settlements. The methodological novelty of this project centers Land-Use and Land-Cover (LULC) analysis of large-scale multispectral satellite imagery to detect and characterize anthropogenic anomalies such as abandoned and unabandoned agricultural infrastructure using semi-automated RS classification. To tie these large-scale characterizations back to ground truth, I will conduct targeted archaeological survey along with UAV-based survey (using UAVs from the Spatial Analysis Research Laboratory [SARL] of Vanderbilt University) to acquire close-range, high-resolution remote sensing imagery. In this way, I envision an integrated multi-scalar “stack” for characterizing colonial era LULC.